Progesterone for the prevention of preterm birth in twin pregnancy (STOPPIT)
نویسندگان
چکیده
Citation for published version: Norman, JE, Mackenzie, F, Owen, P, Mactier, H, Hanretty, K, Cooper, S, Calder, A, Mires, G, Danielian, P, Sturgiss, S, MacLennan, G, Tydeman, G, Thornton, S, Martin, B, Thornton, JG, Neilson, JP & Norrie, J 2009, 'Progesterone for the prevention of preterm birth in twin pregnancy (STOPPIT): a randomised, double-blind, placebo-controlled study and meta-analysis' The Lancet, vol 373, no. 9680, pp. 2034-40. DOI: 10.1016/S0140-6736(09)60947-8
منابع مشابه
Progesterone for the prevention of preterm birth in twin pregnancy (STOPPIT): a randomised, double-blind, placebo-controlled study and meta-analysis
BACKGROUND Women with twin pregnancy are at high risk for spontaneous preterm delivery. Progesterone seems to be effective in reducing preterm birth in selected high-risk singleton pregnancies, albeit with no significant reduction in perinatal mortality and little evidence of neonatal benefit. We investigated the use of progesterone for prevention of preterm birth in twin pregnancy. METHODS I...
متن کاملStudy of progesterone for the prevention of preterm birth in twins (STOPPIT): findings from a trial-based cost-effectiveness analysis.
OBJECTIVES Preterm birth contributes to a range of healthcare problems amongst infants surmounting to sizeable healthcare costs. Twin pregnancies are at particular risk of preterm birth. The objective of this study was to assess the cost-effectiveness of vaginal progesterone gel for the prevention of preterm birth in twin pregnancies. METHODS An economic evaluation was conducted alongside a r...
متن کاملSTOPPIT Baby Follow-Up Study: The Effect of Prophylactic Progesterone in Twin Pregnancy on Childhood Outcome
OBJECTIVES To determine the long-term effects of in utero progesterone exposure in twin children. METHODS This study evaluated the health and developmental outcomes of all surviving children born to mothers who participated in a double-blind, placebo-controlled trial of progesterone given for the prevention of preterm birth in twin pregnancies (STOPPIT, ISRCTN35782581). Follow-up was performe...
متن کاملP-188: Vaginal Progesterone Effects for The Prevention of Preterm Birth and Neonatal Complications in Women at Increased Risk: A Randomized Placebo- Controlled Double-Blind Study
Background: The purpose of this study was to evaluate the effect of prophylactic vaginal progesterone in decreasing preterm birth rate and neonatal complications in a high-risk population. Materials and Methods: A randomized, double-blind, placebo- controlled study included 100 high-risk singleton pregnancies( prior preterm birth,short cervix,uterine malformations and large intramural uterine m...
متن کاملTwin Pregnancy Gestational Length Prolongation and Neonatal Morbidity and Mortality Reduction by Cervical Pessary with or Without Vaginal Progesterone
Purpose: The purpose of this mini review is to elucidate if cervical pessary, with or without progesterone is applicable to twin pregnancies. One-quarter of preterm births (PTB) are twin pregnancies. Cervical cerclage, progesterone, and cervical pessary decrease the PTB incidence in singleton pregnancies. Retrospective cohorts suggest that cervical cerclage is not harmful, and is possibly benef...
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